Anti-inflammatory secondary metabolites from the stems of Millettia dielsiana Harms ex Diels

被引：22

作者：

Le Duc Dat ^{[1
,2
]}

Nguyen Thi Minh Tu ^{[7
]}

Ngo Viet Duc ^{[2
]}

Bui Thi Thuy Luyen ^{[5
]}

Chu Thi Thanh Huyen ^{[5
]}

Jang, Hyun Jae ^{[6
]}

Dang Thi Thu ^{[7
]}

Tran Thu Huong ^{[8
]}

Le Huyen Tram ^{[8
]}

Nguyen Van Thong ^{[8
]}

Nguyen Duc Hung ^{[9
]}

Young Ho Kim ^{[4
]}

Nguyen Phuong Thao ^{[3
]}

机构：

[1] Ton Duc Thang Univ, Inst Computat Sci, Div Computat Phys, Ho Chi Minh City, Vietnam

[2] Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City, Vietnam

[3] VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[4] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea

[5] Hanoi Univ Pharm, 13-15 Le Thanh Tong, Hanoi, Vietnam

[6] Korea Res Inst Biosci & Biotechnol, Immmoregulatory Mat Res Ctr, Jeonbuk 56212, South Korea

[7] Hanoi Univ Sci & Technol, Sch Biotechnol & Food Technol, Hanoi, Vietnam

[8] Hanoi Univ Sci & Technol, Sch Chem Engn, Hanoi, Vietnam

[9] Phutho Coll Med & Pharm, Ctr Drug Res & Technol Transfer, Viettri City, Phutho Province, Vietnam

来源：

CARBOHYDRATE RESEARCH | 2019年 / 484卷

基金：

新加坡国家研究基金会;

关键词：

Millettia dielsiana; Leguminosae; Mildiside A; Phenolic compound; Anti-inflammatory effect; NITRIC-OXIDE; IDENTIFICATION; CONSTITUENTS; FLAVONOIDS; GLYCOSIDES; ROOTS; BIOACTIVITY; INHIBITION; LEAVES;

D O I：

10.1016/j.carres.2019.107778

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A phytochemical investigation for the constituents of the stems of Millettia dielsiana Harms ex Diels resulted in the isolation of a new isoflavone glycoside, mildiside A (1), and 14 known compounds (2-15). Their chemical structures were determined using a combination of IR, NMR, MS, and optical rotation analysis, as well as comparison with the literature data. The ethanolic (EtOH) extract and several isolated compounds exert the inflammatory effect of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cells.

引用

页数：5

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