Colorimetric determination of Cu(II) ions in biological samples using metal-organic framework as scaffold

In this paper we developed a novel optical chemo-sensor for visual detection of Cu(II) ions in the water and biological samples. DDTC/UiO-66 sensor is based on the use of metal-organic frameworks (UiO-66) with its high surface area, morphology and shape in order to obtain a highly sensitive chemo-sensor. Using the designed sensor the naked eye can detect the ultra-trace of Cu(II) ions in a simple, fast, inexpensive way, which is considered the main demand on the new technologies. Calibration curves were constructed byusing two techniques UV-vis Spectrophotometric and Digital Image-based Colorimetric analysis. In the two techniques, the developed chemo-sensor has a wide range of Cu(II) ion detection up to 10(-9) mol/L with a very fast response time. DDTC/UiO-66 sensor can be used to determine the concentration of Cu(II) ions in water and biological samples like blood and serum with very effective results. (C) 2016 Elsevier B.V. All rights reserved.