Ruthenium-catalyzed hydrogenation of aromatic ketones using chiral diamine and monodentate achiral phosphine ligands

被引：7

作者：

Wang, Mengna ^{[1
]}

Zhang, Ling ^{[1
]}

Sun, Hao ^{[1
]}

Chen, Qian ^{[1
]}

Jiang, Jian ^{[1
]}

Li, Linlin ^{[1
]}

Zhang, Lin ^{[1
]}

Li, Li ^{[1
]}

Li, Chun ^{[1
]}

机构：

[1] Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550004, Peoples R China

来源：

CATALYSIS COMMUNICATIONS | 2021年 / 154卷

基金：

中国国家自然科学基金;

关键词：

Chiral diamines; Achiral phosphine; Ruthenium; Enantioselectivity; Ketones;

D O I：

10.1016/j.catcom.2021.106303

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The Ru-catalyzed asymmetric hydrogenation of ketones with chiral diamine and monodentate achiral phosphine has been developed. A wide range of ketones were hydrogenated to afford the corresponding chiral secondary alcohols in good to excellent enantioselectivities (up to 98.1% ee). In addition, an appropriate mechanism for the asymmetric hydrogenation was proposed and verified by NMR spectroscopy.

引用

页数：6

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