Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering

被引：140
|
作者：
Haidar, Ziyad S. [1 ,2 ,3 ,4 ,5 ]
Hamdy, Reggie C. [1 ,4 ,5 ]
Tabrizian, Maryam [1 ,2 ,3 ]
机构：
[1] McGill Univ, Ctr Biorecognit & Biosensors, Montreal, PQ H3A 2B4, Canada
[2] McGill Univ, Dept Biomed Engn, Fac Med, Montreal, PQ H3A 2B4, Canada
[3] McGill Univ, Fac Dent, Montreal, PQ H3A 1A4, Canada
[4] McGill Univ, Shriners Hosp Children, Montreal Childrens Hosp, Montreal, PQ H3A 1A6, Canada
[5] McGill Univ, Div Orthopaed, Montreal Childrens Hosp, Montreal, PQ H3A 1A6, Canada
来源：
BIOTECHNOLOGY LETTERS | 2009年 / 31卷 / 12期
基金：
加拿大健康研究院;
关键词：
Biomaterials; Bone morphogenetic proteins; Bone regeneration; Controlled-release; Nanoparticles; Synthetic polymers; GROWTH-FACTOR DELIVERY; POSTEROLATERAL LUMBAR ARTHRODESIS; SYNTHETIC BIODEGRADABLE POLYMERS; ILIAC CREST AUTOGRAFT; DRUG-DELIVERY; IN-VIVO; RADIOGRAPHIC OUTCOMES; BIOACTIVE MOLECULES; CONTROLLED-RELEASE; GRAFT SUBSTITUTES;
D O I：
10.1007/s10529-009-0100-8
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.
引用
收藏
页码：1825 / 1835
页数：11
相关论文
共 50 条
  • [41] Calcium Phosphate Silicate Microspheres with Soybean Lecithin as a Sustained-Release Bone Morphogenetic Protein-Delivery System for Bone Tissue Regeneration
    Xue, Yaxin
    Li, Yun
    Zhang, Dong
    Xu, Wei
    Han, Dong
    Ning, Congqin
    ACS BIOMATERIALS SCIENCE & ENGINEERING, 2023, 9 (05) : 2596 - 2607
  • [42] Platelet-rich plasma and fibrin as delivery systems for recombinant human bone morphogenetic protein-2
    Jung, RE
    Schmoekel, HG
    Zwahlen, R
    Kokovic, V
    Hammerle, CHF
    Weber, FE
    CLINICAL ORAL IMPLANTS RESEARCH, 2005, 16 (06) : 676 - 682
  • [43] Repair of intercalated long bone defect with biodegradable β-tricalcium phosphate added by a new delivery system for recombinant human bone morphogenetic protein-2.
    Yoneda, M
    Terai, H
    Miyamoto, S
    Takaoka, K
    JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 : S347 - S347
  • [44] Biomimetics and Marine Materials in Drug Delivery and Tissue Engineering: from natural role models to bone regeneration
    Ben-Nissan, Besim
    BIOCERAMICS, VOL 25, 2014, 587 : 229 - 232
  • [45] Calcium Phosphate Nanoparticles-Based Systems for RNAi Delivery: Applications in Bone Tissue Regeneration
    Levingstone, Tanya J.
    Herbaj, Simona
    Redmond, John
    McCarthy, Helen O.
    Dunne, Nicholas J.
    NANOMATERIALS, 2020, 10 (01)
  • [46] Carrageenan-based hydrogels as potential systems for the delivery of PDGF in bone tissue regeneration strategies
    Santo, V. Espirito
    Frias, A. M.
    Gomes, M. E.
    Mano, J. F.
    Reis, R. L.
    TISSUE ENGINEERING PART A, 2008, 14 (05) : 817 - 817
  • [47] Optimal delivery systems for bone morphogenetic proteins in orthopedic applications should model initial tissue repair structures by using a heparin-incorporated fibrin-fibronectin matrix
    Han, Daqing
    Liu, Weiqiang
    Ao, Qiang
    Wang, Guangzhi
    MEDICAL HYPOTHESES, 2008, 71 (03) : 374 - 378
  • [48] Sustained delivery of recombinant human bone morphogenetic protein-2 from perlecan domain I - Functionalized electrospun poly (ε-caprolactone) scaffolds for bone regeneration
    Chiu Y.-C.
    Fong E.L.
    Grindel B.J.
    Kasper F.K.
    Harrington D.A.
    Farach-Carson M.C.
    Journal of Experimental Orthopaedics, 3 (1)
  • [49] The application of energetic SHS reactions in the synthesis of multifunctional bone tissue engineering and drug delivery systems
    Ayers, R.
    Burkes, D.
    Gottoli, G.
    Yi, H. C.
    Guigne, J. Y.
    Moore, J. J.
    MULTIFUNCTIONAL ENERGETIC MATERIALS, 2006, 896 : 25 - +
  • [50] Review of nanomembranes: materials, fabrications and applications in tissue engineering (bone and skin) and drug delivery systems
    Cigane, Urte
    Palevicius, Arvydas
    Janusas, Giedrius
    JOURNAL OF MATERIALS SCIENCE, 2021, 56 (24) : 13479 - 13498
12345