Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering

被引：140

作者：

Haidar, Ziyad S. ^{[1
,2
,3
,4
,5
]}

Hamdy, Reggie C. ^{[1
,4
,5
]}

Tabrizian, Maryam ^{[1
,2
,3
]}

机构：

[1] McGill Univ, Ctr Biorecognit & Biosensors, Montreal, PQ H3A 2B4, Canada

[2] McGill Univ, Dept Biomed Engn, Fac Med, Montreal, PQ H3A 2B4, Canada

[3] McGill Univ, Fac Dent, Montreal, PQ H3A 1A4, Canada

[4] McGill Univ, Shriners Hosp Children, Montreal Childrens Hosp, Montreal, PQ H3A 1A6, Canada

[5] McGill Univ, Div Orthopaed, Montreal Childrens Hosp, Montreal, PQ H3A 1A6, Canada

来源：

BIOTECHNOLOGY LETTERS | 2009年 / 31卷 / 12期

基金：

加拿大健康研究院;

关键词：

Biomaterials; Bone morphogenetic proteins; Bone regeneration; Controlled-release; Nanoparticles; Synthetic polymers; GROWTH-FACTOR DELIVERY; POSTEROLATERAL LUMBAR ARTHRODESIS; SYNTHETIC BIODEGRADABLE POLYMERS; ILIAC CREST AUTOGRAFT; DRUG-DELIVERY; IN-VIVO; RADIOGRAPHIC OUTCOMES; BIOACTIVE MOLECULES; CONTROLLED-RELEASE; GRAFT SUBSTITUTES;

D O I：

10.1007/s10529-009-0100-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.

引用

页码：1825 / 1835

页数：11

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