Cooperation of MT1-MMP and LOX-1 for RhoA- and Rac1-dependent Signaling Pathways in Oxidized LDL-mediated Endothelial Dysfunction and Atherosclerosis

被引：0

作者：

Sugimoto, Koichi ^{[1
]}

Ishibashi, Toshiyuki ^{[1
]}

Sawamura, Tatsuya ^{[2
]}

Uekita, Hironori ^{[1
]}

Kamioka, Masashi ^{[1
]}

Inoue, Nobutaka ^{[2
]}

Shiomi, Masashi ^{[3
]}

Takuwa, Yoh ^{[4
]}

Teramoto, Tamio ^{[5
]}

Takeishi, Yasuchika ^{[1
]}

机构：

[1] Fukushima Med Univ, Dept Cardiol & Hematol, Fukushima, Japan

[2] Natl Cardiovasc Ctr, Res Inst, Dept Biosci, Osaka, Japan

[3] Kobe Univ, Sch Med, Inst Expt Anim, Kobe, Hyogo 650, Japan

[4] Kanazawa Univ, Sch Med, Dept Physiol, Kanazawa, Ishikawa 920, Japan

[5] Teikyo Univ, Sch Med, Dept Internal Med, Tokyo 173, Japan

来源：

CIRCULATION | 2009年 / 120卷 / 18期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：S1119 / S1120

页数：2

共 34 条

[1] Membrane type matrix metalloproteinase-1 (MT1-MMP) is a cell surface modifier of RhoA/Rac1-mediated signaling pathways and forms a complex with LOX-1 in oxidized LDL-induced endothelial dysfunction
Sugimoto, K.
Ishibashi, T.
Sawamura, T.
Kamioka, M.
Uekita, H.
Ohkawara, H.
Inoue, N.
Takuwa, Y.
Teramoto, T.
Takeishi, Y.
EUROPEAN HEART JOURNAL, 2009, 30 : 727 - 727
[2] Crucial Role of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) in RhoA/Rac1-Dependent Signaling Pathways in Thrombin-Stimulated Endothelial Cells
Ando, Katsuya
Ishibashi, Toshiyuki
Ohkawara, Hiroshi
Inoue, Nobutaka
Sugimoto, Koichi
Uekita, Hironori
Hu, Chengjun
Okamoto, Yasuo
Takuwa, Yoh
Takeishi, Yasuchika
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2011, 18 (09) : 762 - 773
[3] Interaction of carbamylated LDL with LOX-1 in the induction endothelial dysfunction and atherosclerosis
Mehta, Jawahar L.
Basnakian, Alexei G.
EUROPEAN HEART JOURNAL, 2014, 35 (43) : 2996 - 2997
[4] Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells
Lee, Wen-Jane
Ou, Hsiu-Chung
Hsu, Wen-Cheng
Chou, Min-Min
Tseng, Jenn-Jhy
Hsu, Shih-Lan
Tsai, Kun-Ling
Sheu, Wayne Huey-Herng
JOURNAL OF VASCULAR SURGERY, 2010, 52 (05) : 1290 - 1300
[5] Oxidized LDL-Cholesterol induces endothelial dysfunction and LOX-1 in human macrophages
Leuner, A.
Poitz, D. M.
Brunssen, C.
Ravens, U.
Strasser, R. H.
Morawietz, H.
CARDIOVASCULAR RESEARCH, 2012, 93 : S117 - S117
[6] Inhibition of membrane type 1-matrix metalloproteinase (MT1-MMP) prevents Lox-1-mediated RhoA and Rac-1 activation induced by oxidized low-density lipoprotein
Sugimoto, K
Ishibashi, T
Ohkawara, H
Sugimoto, N
Sakamoto, T
Kamioka, M
Sakamoto, N
Teramoto, T
Sawamura, T
Kurabayashi, M
Maruyama, Y
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2005, 39 (06) : 999 - 999
[7] LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells
Sugimoto, Koichi
Ishibashi, Toshiyuki
Sawamura, Tatsuya
Inoue, Nobutaka
Kamioka, Masashi
Uekita, Hironori
Ohkawara, Hiroshi
Sakamoto, Takayuki
Sakamoto, Nobuo
Okamoto, Yasuo
Takuwa, Yoh
Kakino, Akemi
Fujita, Yoshiko
Tanaka, Takeshi
Teramoto, Tamio
Maruyama, Yukio
Takeishi, Yasuchika
CARDIOVASCULAR RESEARCH, 2009, 84 (01) : 127 - 136
[8] Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells
Li, DY
Mehta, JL
CIRCULATION, 2000, 101 (25) : 2889 - 2895
[9] New Insights of LOX-1-MT1-MMP Axis into RhoA and Rac1 Activation Induced by Oxidized Low-Density Lipoprotein in Endothelial Cells
Sugimoto, Koichi
Ishibashi, Toshiyuki
Sawamura, Tatsuya
Uekita, Hironori
Takuwa, Yoh
Teramoto, Tamio
Shiomi, Masashi
Takeishi, Yasuchika
CIRCULATION RESEARCH, 2009, 105 (07) : E38 - E38
[10] LOX-1, an endothelial receptor for oxidized LDL - Implications for induction of endothelium dysfunction in the pathogenesis of vascular diseases
Sawamura, T
Kakutani, M
Chen, MY
Masaki, T
LIPOPROTEIN METABOLISM AND ATHEROGENESIS, 2000, : 193 - 198

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