(R)-1-Arylethanols from aryl iodides through a two-step one-pot enantioselective chemoenzymatic process

被引：9

作者：

Cacchi, Sandro ^{[3
]}

Cirilli, Roberto ^{[2
]}

Fabrizi, Giancarlo ^{[3
]}

Sgalla, Simona ^{[2
]}

Macone, Alberto ^{[1
]}

Bonamore, Alessandra ^{[1
]}

Boffi, Alberto ^{[1
]}

机构：

[1] Univ Rome, Dipartimento Sci Biochim Sapienza, I-00185 Rome, Italy

[2] Ist Super Sanita, I-00161 Rome, Italy

[3] Univ Roma La Sapienza, Dipartimento Chim & Tecnol Farm, I-00185 Rome, Italy

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2009年 / 61卷 / 3-4期

关键词：

Asimmetric synthesis; Palladium catalysis; Alcohol dehydrogenase; ASYMMETRIC TRANSFER HYDROGENATION; DYNAMIC KINETIC RESOLUTION; PROCHIRAL KETONES; COMPLEXES; REDUCTION; CATALYST; MECHANISM; ALCOHOLS; LIGANDS;

D O I：

10.1016/j.molcatb.2009.06.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(R)-1-Arylethanols have been prepared in high to excellent overall yields through a two-step one-pot process that involves the palladium-catalyzed conversion of aryl iodides into the corresponding acetophenones, in the presence of acetic anhydride. EtN(i-Pr)(2), LiCl, and Pd-2(dba)(3) followed by an enantioselective reduction step catalyzed by the alcohol dehydrogenase enzyme from Lactobacillus brevis. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：184 / 187

页数：4

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