(R)-1-Arylethanols from aryl iodides through a two-step one-pot enantioselective chemoenzymatic process

被引：9
|
作者：
Cacchi, Sandro [3 ]
Cirilli, Roberto [2 ]
Fabrizi, Giancarlo [3 ]
Sgalla, Simona [2 ]
Macone, Alberto [1 ]
Bonamore, Alessandra [1 ]
Boffi, Alberto [1 ]
机构：
[1] Univ Rome, Dipartimento Sci Biochim Sapienza, I-00185 Rome, Italy
[2] Ist Super Sanita, I-00161 Rome, Italy
[3] Univ Roma La Sapienza, Dipartimento Chim & Tecnol Farm, I-00185 Rome, Italy
来源：
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2009年 / 61卷 / 3-4期
关键词：
Asimmetric synthesis; Palladium catalysis; Alcohol dehydrogenase; ASYMMETRIC TRANSFER HYDROGENATION; DYNAMIC KINETIC RESOLUTION; PROCHIRAL KETONES; COMPLEXES; REDUCTION; CATALYST; MECHANISM; ALCOHOLS; LIGANDS;
D O I：
10.1016/j.molcatb.2009.06.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(R)-1-Arylethanols have been prepared in high to excellent overall yields through a two-step one-pot process that involves the palladium-catalyzed conversion of aryl iodides into the corresponding acetophenones, in the presence of acetic anhydride. EtN(i-Pr)(2), LiCl, and Pd-2(dba)(3) followed by an enantioselective reduction step catalyzed by the alcohol dehydrogenase enzyme from Lactobacillus brevis. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：184 / 187
页数：4
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