ONE-POT SYNTHESIS OF DIHYDROPYRIMIDIONES VIA ENVIRONMENTALLY FRIENDLY ENZYME-CATALYZED BIGINELLI REACTION

被引：12
|
作者：
Li, Wanmei [1 ]
Zhou, Guobin [1 ]
Zhang, Pengfei [1 ]
Lai, Yifeng [1 ]
Xu, Shifu [1 ]
机构：
[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China
来源：
HETEROCYCLES | 2011年 / 83卷 / 09期
关键词：
Enzyme-Catalyzed Reaction; One-Pot Synthesis; Dihydropyrimidione; Environmentally Benign Reaction; SOLVENT-FREE CONDITIONS; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; IONIC LIQUID; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; CONDENSATION; CHLORIDE; KNOEVENAGEL; PROMISCUITY; CHEMISTRY;
D O I：
10.3987/COM-11-12267
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel enzyme-catalyzed Biginelli reaction of acetoacetate, aromatic aldehyde and urea (thiourea) was described. Great acceleration of the one-pot multicomponent reaction was observed by the aid of enzymes. Various dihydropyrimidiones were prepared in good yields under the conditions using trypsin from porcine pancreas as the catalyst.
引用
收藏
页码：2067 / 2077
页数：11
相关论文
共 50 条
  • [41] Synthesis of functionalized PEEK analouges via one-pot reaction
    Ewing, Zachary
    Fossum, Eric
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [42] One-pot enzyme-catalyzed synthesis of dual-functional polyester macromers towards surface-active hydrophobic films
    Nameer, Samer
    Semlitsch, Stefan
    Martinelle, Mats
    Johansson, Mats
    RSC ADVANCES, 2017, 7 (79): : 50294 - 50299
  • [43] One-pot three-component Biginelli-type reaction catalyzed by ionic liquids in aqueous media
    Dong Fang
    Dai-zhen Zhang
    Zu-liang Liu
    Monatshefte für Chemie - Chemical Monthly, 2010, 141 : 419 - 423
  • [44] One-pot three-component Biginelli-type reaction catalyzed by ionic liquids in aqueous media
    Fang, Dong
    Zhang, Dai-zhen
    Liu, Zu-liang
    MONATSHEFTE FUR CHEMIE, 2010, 141 (04): : 419 - 423
  • [45] Environmentally friendly synthesis of secondary amines via one-pot reductive amination over a heterogeneous Co-Nx catalyst
    Jiang, Liang
    Zhou, Peng
    Zhang, Zehui
    Chi, Quan
    Jin, Shiwei
    NEW JOURNAL OF CHEMISTRY, 2017, 41 (20) : 11991 - 11997
  • [46] Pd-Catalyzed one-pot synthesis of vinylsilanes via a three-component tandem reaction
    Li, Wenguang
    Zhang, Chao
    Lu, Haiyan
    Wang, Yajun
    Deng, Guobo
    Liang, Yun
    Yang, Yuan
    ORGANIC CHEMISTRY FRONTIERS, 2020, 7 (15) : 2075 - 2081
  • [47] Facile Synthesis of Isoindolinones via Rh(III)-Catalyzed One-Pot Reaction of Benzamides, Ketones, and Hydrazines
    Zhang, Yan
    Wang, Dahai
    Cui, Sunliang
    ORGANIC LETTERS, 2015, 17 (10) : 2494 - 2497
  • [48] Sulfamic Acid Catalyzed One-Pot Synthesis of Polyhydroquinolines via the Hantzsch Four Component Condensation Reaction
    Foroughifar, Naser
    Mobinikhaledi, Akbar
    Fard, Mohammad Ali Bodaghi
    Moghanian, Hassan
    Ebrahimi, Sattar
    SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY, 2009, 39 (03) : 161 - 164
  • [49] Green Synthesis of Spirooxindoles via Lipase-Catalyzed One-Pot Tandem Reaction in Aqueous Media
    Tang, Yong
    Wang, Ciduo
    Xie, Hanqing
    Xu, Yuelin
    Wang, Chunyu
    Du, Chuang
    Wang, Zhi
    Wang, Lei
    CATALYSTS, 2023, 13 (01)
  • [50] Synthesis of Biologically Active Indenoisoquinoline Derivatives via a One-Pot Copper(II)-Catalyzed Tandem Reaction
    Huang, Chia-Yu
    Kavala, Veerababurao
    Kuo, Chun-Wei
    Konala, Ashok
    Yang, Tang-Hao
    Yao, Ching-Fa
    JOURNAL OF ORGANIC CHEMISTRY, 2017, 82 (04): : 1961 - 1968
12345