ONE-POT SYNTHESIS OF DIHYDROPYRIMIDIONES VIA ENVIRONMENTALLY FRIENDLY ENZYME-CATALYZED BIGINELLI REACTION

被引：12
|
作者：
Li, Wanmei [1 ]
Zhou, Guobin [1 ]
Zhang, Pengfei [1 ]
Lai, Yifeng [1 ]
Xu, Shifu [1 ]
机构：
[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China
来源：
HETEROCYCLES | 2011年 / 83卷 / 09期
关键词：
Enzyme-Catalyzed Reaction; One-Pot Synthesis; Dihydropyrimidione; Environmentally Benign Reaction; SOLVENT-FREE CONDITIONS; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; IONIC LIQUID; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; CONDENSATION; CHLORIDE; KNOEVENAGEL; PROMISCUITY; CHEMISTRY;
D O I：
10.3987/COM-11-12267
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel enzyme-catalyzed Biginelli reaction of acetoacetate, aromatic aldehyde and urea (thiourea) was described. Great acceleration of the one-pot multicomponent reaction was observed by the aid of enzymes. Various dihydropyrimidiones were prepared in good yields under the conditions using trypsin from porcine pancreas as the catalyst.
引用
收藏
页码：2067 / 2077
页数：11
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