Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin

被引：124

作者：

Liang, Guang ^{[1
,2
]}

Li, Xiaokun ^{[1
,3
,4
]}

Chen, Li ^{[2
]}

Yang, Shulin ^{[3
]}

Wu, Xudong ^{[2
]}

Studer, Elaine ^{[2
]}

Gurley, Emily ^{[2
]}

Hylemon, Phillip B. ^{[2
]}

Ye, Faqing ^{[1
]}

Li, Yueru ^{[4
]}

Zhou, Huiping ^{[1
,2
]}

机构：

[1] Wenzhou Med Coll, Coll Pharm, Wenzhou 325035, Peoples R China

[2] Virginia Commonwealth Univ, Sch Med, Dept Microbiol & Immunol, Richmond, VA 23298 USA

[3] Nanjing Univ Sci& Technol, Coll Chem, Nanjing 210049, Peoples R China

[4] Jilin Agr Univ, Minist Educ, Engn Res Ctr Bioreactor & Pharmaceut Dev, Changchun 130118, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 04期

关键词：

curcumin; anti-inflammation; TNF-alpha; IL-6;

D O I：

10.1016/j.bmcl.2007.12.068

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Curcumin has been extensively studied for its anti-inflammatory activities. However, its potential beneficial effects on various disease preventions and treatments are limited by its unstable structure. The beta-diketone moiety renders curcumin to be rapidly metabolized by aldo -keto reductase in liver. In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide ( LPS)-induced TNF-alpha and IL-6 synthesis in macrophages. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1525 / 1529

页数：5

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