Autophagy in major human diseases

被引：1021

作者：

Klionsky, Daniel J. ^{[1
]}

Petroni, Giulia ^{[2
]}

Amaravadi, Ravi K. ^{[3
,4
]}

Baehrecke, Eric H. ^{[5
]}

Ballabio, Andrea ^{[6
,7
,8
,9
]}

Boya, Patricia ^{[10
]}

Bravo-San Pedro, Jose Manuel ^{[11
,12
]}

Cadwell, Ken ^{[13
,14
,15
]}

Cecconi, Francesco ^{[16
,17
,18
]}

Choi, Augustine M. K. ^{[19
,20
]}

Choi, Mary E. ^{[20
,21
]}

Chu, Charleen T. ^{[22
]}

Codogno, Patrice ^{[23
,24
]}

Colombo, Maria Isabel ^{[25
]}

Cuervo, Ana Maria ^{[26
,27
]}

Deretic, Vojo ^{[28
,29
]}

Dikic, Ivan ^{[30
,31
]}

Elazar, Zvulun ^{[32
]}

Eskelinen, Eeva-Liisa ^{[33
]}

Fimia, Gian Maria ^{[34
,35
]}

Gewirtz, David A. ^{[36
]}

Green, Douglas R. ^{[37
]}

Hansen, Malene ^{[38
]}

Jaattela, Marja ^{[39
,40
]}

Johansen, Terje ^{[41
]}

Juhasz, Gabor ^{[42
,43
]}

Karantza, Vassiliki ^{[44
]}

Kraft, Claudine ^{[45
,46
]}

Kroemer, Guido ^{[47
,48
,49
,50
,51
]}

Ktistakis, Nicholas T. ^{[52
]}

Kumar, Sharad ^{[53
,54
]}

Lopez-Otin, Carlos ^{[55
,56
]}

Macleod, Kay F. ^{[57
,58
]}

Madeo, Frank ^{[59
,60
,61
]}

Martinez, Jennifer ^{[62
]}

Melendez, Alicia ^{[63
,64
,65
]}

Mizushima, Noboru ^{[66
]}

Munz, Christian ^{[67
]}

Penninger, Josef M. ^{[68
,69
]}

Perera, Rushika M. ^{[70
,71
,72
]}

Piacentini, Mauro ^{[18
,73
]}

Reggiori, Fulvio ^{[74
]}

Rubinsztein, David C. ^{[75
,76
]}

Ryan, Kevin M. ^{[77
,78
]}

Sadoshima, Junichi ^{[79
]}

Santambrogio, Laura ^{[2
,80
,81
]}

Scorrano, Luca ^{[82
,83
]}

Simon, Hans-Uwe ^{[84
,85
,86
]}

Simon, Anna Katharina ^{[87
]}

Simonsen, Anne ^{[88
,89
,90
]}

机构：

[1] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA

[2] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 10065 USA

[3] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[4] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[5] Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, Worcester, MA USA

[6] Telethon Inst Genet & Med, Pozzuoli, Italy

[7] Univ Naples Federico II, Dept Translat Med Sci, Sect Pediat, Naples, Italy

[8] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[9] Texas Children Hosp, Jan & Duncan Neurol Res Inst, Houston, TX USA

[10] Spanish Natl Res Council, Margarita Salas Ctr Biol Res, Madrid, Spain

[11] Univ Complutense Madrid, Fac Med, Dept Sect Physiol, Madrid, Spain

[12] Ctr Networked Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain

[13] NYU, Kimmel Ctr Biol & Med, Grossman Sch Med, Skirball Inst, New York, NY USA

[14] NYU, Dept Microbiol, Grossman Sch Med, New York, NY 10016 USA

[15] New York Univ Langone Hlth, Dept Med, Div Gastroenterol & Hepatol, New York, NY USA

[16] Danish Canc Soc, Ctr Autophagy Recycling & Dis CARD, Cell Stress & Survival Unit, Res Ctr, Copenhagen, Denmark

[17] IRCCS Bambino Gesu Childrens Hosp, Dept Pediat Oncohematol & Cell & Gene Therapy, Rome, Italy

[18] Univ Roma Tor Vergata, Dept Biol, Rome, Italy

[19] Weill Cornell Med, Div Pulm & Crit Care Med, Joan & Sanford I Weill Dept Med, New York, NY USA

[20] Weill Cornell Med, New York Presbyterian Hosp, New York, NY USA

[21] Weill Cornell Med, Div Nephrol & Hypertens, Joan & Sanford I Weill Dept Med, New York, NY USA

[22] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA

[23] Inst Necker Enfants Malad, INSERM U1151 CNRS UMR 8253, Paris, France

[24] Univ Paris, Paris, France

[25] Univ Nacl Cuyo, CONICET Fac Ciencias Med, Lab Mecanismos Mol Implicados Traf Vesicular & Au, Inst Histol & Embriol IHEM, Mendoza, Argentina

[26] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10467 USA

[27] Albert Einstein Coll Med, Inst Aging Studies, Bronx, NY 10467 USA

[28] Univ New Mexico, Ctr Biomed Res Excellence, Autophagy Inflammat & Metab AIM, Hlth Sci Ctr, Albuquerque, NM 87131 USA

[29] Univ New Mexico, Dept Mol Genet & Microbiol, Hlth Sci Ctr, Albuquerque, NM 87131 USA

[30] Goethe Univ, Sch Med, Inst Biochem 2, Frankfurt, Germany

[31] Goethe Univ, Buchmann Inst Mol Life Sci, Frankfurt, Germany

[32] Weizmann Inst Sci, Dept Biomol Sci, Rehovot, Israel

[33] Univ Turku, Inst Biomed, Turku, Finland

[34] Sapienza Univ Rome, Dept Mol Med, Rome, Italy

[35] Natl Inst Infect Dis L Spallanzani IRCCS, Dept Epidemiol Preclin Res & Adv Diagnost, Rome, Italy

[36] Virginia Commonwealth Univ, Sch Med, Dept Pharmacol & Toxicol, Richmond, VA USA

[37] St Jude Childrens Res Hosp, Dept Immunol, 332 N Lauderdale St, Memphis, TN 38105 USA

[38] Sanford Burnham Prebys Med Discovery Inst, Program Dev Aging & Regenerat, La Jolla, CA USA

[39] Danish Canc Soc, Ctr Autophagy Recycling & Dis, Res Ctr, Cell Death & Metab, Copenhagen, Denmark

[40] Univ Copenhagen, Fac Hlth Sci, Dept Cellular & Mol Med, Copenhagen, Denmark

[41] Univ Tromso, Dept Med Biol, Arctic Univ Norway, Mol Canc Res Grp, Tromso, Norway

[42] Biol Res Ctr, Inst Genet, Szeged, Hungary

[43] Eotvos Lorand Univ, Dept Anat Cell & Dev Biol, Budapest, Hungary

[44] Merck & Co Inc, Kenilworth, NJ USA

[45] Univ Freiburg, Fac Med, Inst Biochem & Mol Biol, ZBMZ, Freiburg, Germany

[46] Univ Freiburg, CIBSS Ctr Integrat Biol Signalling Studies, Freiburg, Germany

[47] Univ Paris, Sorbonne Univ, Inst Univ France,Inserm U1138, Ctr Rech Cordeliers,Equipe Bellisee Ligue Canc, Paris, France

[48] Inst Gustave Roussy, Metabol & Cell Biol Platforms, Villejuif, France

[49] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[50] Chinese Acad Med Sci, Suzhou Inst Syst Med, Suzhou, Peoples R China

来源：

EMBO JOURNAL | 2021年 / 40卷 / 19期

关键词：

aging; cancer; inflammation; metabolic syndromes; neurodegeneration; CHAPERONE-MEDIATED AUTOPHAGY; ENDOPLASMIC-RETICULUM STRESS; ENDOMETRIAL STROMAL CELLS; LIFE-SPAN EXTENSION; SELECTIVE AUTOPHAGY; MOLECULAR-MECHANISMS; ALPHA-SYNUCLEIN; MOUSE MODEL; MUTANT HUNTINGTIN; PROMOTES GROWTH;

D O I：

10.15252/embj.2021108863

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

引用

页数：64

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