ADENOSINE A3 RECEPTORS: A NEW THERAPEUTIC APPROACH IN CANCER.

被引：2

作者：

Gaspar, Alexandra ^{[1
]}

Silva, Tiago ^{[1
]}

Borges, Fernanda ^{[1
]}

机构：

[1] Univ Porto, Fac Ciencias, Dept Quim & Bioquim, P-4000 Oporto, Portugal

来源：

QUIMICA NOVA | 2011年 / 34卷 / 08期

关键词：

cancer; AR A(3); ligands; HIGHLY POTENT; SPECIES-DIFFERENCES; PHARMACOLOGICAL EVALUATION; SELECTIVE ANTAGONISTS; PURINE DERIVATIVES; MELANOMA-CELLS; LIGANDS; AGONISTS; SERIES; AFFINITY;

D O I：

10.1590/S0100-40422011000800022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

ADENOSINE A(3) RECEPTORS: A NEW THERAPEUTIC APPROACH IN CANCER. Cancer is a multi-factorial disease linked with different initiating causes, cofactors and promoters, and several types of cellular damage. Advancing knowledge on the cellular and molecular biology of the processes that regulate cell proliferation, cell differentiation and cellular responses to external signals, has provided a wealth of information about the cancer cell and how it differs from a normal one. These findings make available a number of potential targets for new therapeutic approaches. The Medicinal Chemistry artwork performed so far in the development of selective and potent adenosine receptor A(3) ligands, a current cancer target, will be highlighted in this work.

引用

页码：1417 / 1424

页数：8

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