Upregulation of ZBTB7A exhibits a tumor suppressive role in gastric cancer cells

被引：16
|
作者：
Sun, Guang [1 ]
Peng, Bo [1 ]
Xie, Quan [1 ]
Ruan, Jianwen [1 ]
Liang, Xianwen [1 ]
机构：
[1] Cent S Univ, Dept Surg Gastroenterol, Affiliated Haikou Hosp, Haikou Municipal Peoples Hosp,Xiangya Sch Med, 43 Renmin Rd, Haikou 570208, Hainan, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2018年 / 17卷 / 02期
关键词：
gastric cancer; zinc finger and BTB domain containing 7A; apoptosis; migration; cell cycle; LEUKEMIA/LYMPHOMA-RELATED FACTOR; COPY-NUMBER ALTERATION; TRANSCRIPTIONAL REPRESSOR; GENE-EXPRESSION; LUNG-CANCER; POZ DOMAIN; OVEREXPRESSION; METASTASIS; POKEMON; PROTEIN;
D O I：
10.3892/mmr.2017.8104
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastric cancer presents as a complex solid tumor and is the third leading cause of global cancer-associated mortality. The genetic alterations in gastric cancer remain unclear and deserve further investigation. Mining The Cancer Genome Atlas gastric adenocarcinoma dataset identified a frequent loss of the zinc finger and BTB domain containing 7A (ZBTB7A) gene locus and a significant correlation between low ZBTB7A expression and poor patient survival. ZBTB7A belongs to the POZ/BTB and Kruppel transcription factor family. In the present study, overexpression of ZBTB7A in a gastric cancer cell line induced cell cycle arrest at the S phase. Upregulation of ZBTB7A also promoted apoptosis and repressed cell migration. The results of the present study indicated that ZBTB7A functions as a tumor suppressor in gastric cancer cells. Understanding the role of ZBTB7A in gastric cancer may provide important clinical insight for treatment.
引用
收藏
页码：2635 / 2641
页数：7
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