Synthesis of 3,3-Dialkyl-Substituted Isoindolinones Enabled by Nickel-Catalyzed Reductive Dicarbofunctionalization of Enamides

被引：34
|
作者：
Fang, Ke [1 ,2 ]
Huang, Wenyi [1 ,2 ]
Shan, Chunxiao [1 ,2 ]
Qu, Jingping [1 ,2 ]
Chen, Yifeng [1 ,2 ]
机构：
[1] East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai 200237, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 14期
基金：
上海市自然科学基金;
关键词：
ARYL-ALKENYLATION;
D O I：
10.1021/acs.orglett.1c01871
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we report the nickel-catalyzed reductive dicarbofunctionalization of 1,1-disubstituted enamides with unactivated alkyl iodides to access the 3,3-dialkyl-substituted isoindolinone frameworks. This tandem cyclization/reductive coupling protocol exhibits broad functional group tolerance under mild conditions. The utilization of commercially accessible chiral Bn-Biox ligand allows excellent enantioselectivities to forge the tetrasubstituted stereocenters.
引用
收藏
页码：5523 / 5527
页数：5
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