Pyridazine N-oxides .1. Synthesis and in vitro antimicrobial evaluation of 3-methyl-4-aryl-6-R-pyridazine N-oxides

被引：0
|
作者：
Gavini, E
Juliano, C
Mule, A
Pirisino, G
Pinna, GA
Curzu, MM
机构：
[1] UNIV SASSARI,DIPARTIMENTO SCI FARMACO,I-07100 SASSARI,ITALY
[2] UNIV SASSARI,IST CHIM FARMACEUT,I-07100 SASSARI,ITALY
来源：
FARMACO | 1996年 / 51卷 / 10期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A new series of 3-methyl-4-aryl-6-R-pyridazine N-oxides 1a-j, structurally related to known antifungal agents azoxybacilin and pyridazomycin, has been prepared and evaluated for their in vitro antimicrobial activity. Among the compounds synthesized only 1g and 1h showed a fair activity against Gram-positive Staphylococcus epidermidis and Staphylococcus aureus.
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页码：683 / 688
页数：6
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