Differential expression profiles and functional analysis of circular RNAs in children with fulminant myocarditis

被引：22

作者：

Zhang, Li ^{[1
]}

Han, Bo ^{[1
]}

Wang, Jing ^{[1
]}

Liu, Qingqing ^{[1
]}

Kong, Yaru ^{[1
]}

Jiang, Diandong ^{[1
]}

Jia, Hailin ^{[1
]}

机构：

[1] Shandong Univ, Dept Pediat Cardiol, Shandong Prov Hosp, 324 Jingwuweiqi Rd, Jinan 250021, Shandong, Peoples R China

来源：

EPIGENOMICS | 2019年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

circular RNA; fulminant myocarditis; functional analysis; hsa_circ_0071542; microarray; CARDIOMYOPATHY; PROGRESSION; PATHWAY; MODEL;

D O I：

10.2217/epi-2019-0101

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: To assess differential expression profiles of circular RNAs (circRNAs) and explore their possible functions in children with fulminant myocarditis. Materials & methods: circRNA microarray experiments were carried out for determining differential expression profiles of circRNAs in three children with fulminant myocarditis and three healthy volunteers. Functional analysis and circRNA-miRNA-mRNA interaction network building were conducted to study biological functions. Results: This work identified 2281 upregulated and 892 downregulated circRNAs. Further assessment confirmed hsa_circ_0071542 upregulation (2.5-fold) in fulminant myocarditis. Functional analysis demonstrated the differentially expressed circRNAs mainly contributed to inflammation and immunity. Conclusion: circRNAs might have substantial roles in pediatric fulminant myocarditis, and hsa_circ_0071542 could serve as a promising biomarker.

引用

页码：1129 / 1142

页数：14

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