Epidemiology of Breast Cancer in Mexican Women with Obesity as a Risk Factor

被引:3
|
作者
Cejudo-Arteaga, Shaila [1 ]
Angel Guerrero-Ramos, Miguel [2 ]
Kuri-Exome, Roberto [2 ]
Martinez-Cordero, Erika [3 ]
Farias-Serratos, Felipe [3 ]
Maldonado-Vega, Maria [3 ]
机构
[1] Benemerita Univ Autonoma Puebla, Fac Med, Colonia Ctr, 4 Sur 104, Puebla 72420, Mexico
[2] Hosp Reg Alta Especialidad Bajio, Serv Oncol Med, Blvd Milenio 130, Colonia San Carlos La Ro 37660, Leon, Mexico
[3] Hosp Reg Alta Especialidad Bajio, Direcc Planeac Ensenanza & Invest, Unidad Ensenanza & Invest, Blvd Milenio 130, Colonia San Carlos La Ro 37660, Leon, Mexico
关键词
obesity; Mexican women; breast cancer; Ag CEA; Ag CA15-3; recurrence; macrophages; INFLAMMATION;
D O I
10.3390/ijms231810742
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Purpose. Adipose tissue in overweight and obesity shows metabolic imbalance in the function of adipocytes and macrophages, this leads to altered regulation of hunger, lipid storage, and chronic inflammation possibly related to the development of breast cancer. Methods. The study was retrospective of 653 breast cancer patients treated at a tertiary care hospital. Histopathology, hormone receptors, grade, clinical stage, clinical biometry analysis, CEA and CA 15-3 antigens were analyzed. The analyses were performed at diagnosis and at the end of oncological treatments. Results. Mexican women studied and treated for breast cancer have an BMI of 29 from diagnosis and at the end of their cancer treatments. The average age was 52 +/- 12 years, 54% in women older than 55 years. Cancer recurrence occurs in any molecular type; however, the common factor was overweight and obesity with 73% vs. 21% in normal weight patients. The most frequent tumor tissue in the population was positive hormone receptors of the luminal type (65%), HER2 (15%), and NT (15%). The analyses of macrophages/lymphocytes (M/L), CEA, and CA 15-3 antigens evaluated in women >55 and <55 years, with and without recurrence are elevated at the end of oncological treatments. Conclusions. The analysis of Mexican women with breast cancer showed a predominance of overweight and obesity at diagnosis and at the end of treatment. A relationship between obesity and cancer recurrence with a low response to treatment due to elevation in Ag CEA and CA 15-3 is suggested. The L/M ratio could be an indicator of inflammation related to adipose tissue since diagnosis.
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页数:10
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