The desensitizing effect of chronic elevation of free fatty acids (FFA) on glucose-stimulated secretion of insulin is accentuated in vivo in lean ZDF rats

被引:0
|
作者
Goh, TT
Mason, TM
Gupta, N
Lam, T
So, A
Lewis, GF
Giacca, A
机构
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1219
引用
收藏
页码:A279 / A279
页数:1
相关论文
共 50 条
  • [41] Effect of modified glucose-insulin-potassium on free fatty acids, matrix metalloproteinase, and myoglobin in ST-elevation myocardial infarction
    Chaudhuri, Ajay
    Janicke, David
    Wilson, Michael
    Ghanim, Husam
    Wilding, Gregory E.
    Aljada, Ahmad
    Dandona, Paresh
    AMERICAN JOURNAL OF CARDIOLOGY, 2007, 100 (11): : 1614 - 1618
  • [42] EFFECT OF BODY-WEIGHT ON FASTING PROFILES OF SERUM-INSULIN, GLUCOSE, FREE FATTY-ACIDS (FFA) AND TRIGLYCERIDES (TGS) IN HUMAN-PREGNANCY
    SINGH, R
    MARTIN, RJ
    FASEB JOURNAL, 1988, 2 (04): : A644 - A644
  • [43] Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats
    Akimoto, Yoshihiro
    Hart, Gerald W.
    Wells, Lance
    Vosseller, Keith
    Yamamoto, Koji
    Munetomo, Eiji
    Ohara-Imaizumi, Mica
    Nishiwaki, Chiyono
    Nagamatsu, Shinya
    Hirano, Hiroshi
    Kawakami, Hayato
    GLYCOBIOLOGY, 2007, 17 (02) : 127 - 140
  • [44] THE EFFECT OF GLUCOSE AND FREE FATTY-ACIDS ON GROWTH-HORMONE (GH) RELEASING FACTOR-MEDIATED GH SECRETION IN RATS
    IMAKI, T
    SHIBASAKI, T
    MASUDA, A
    HOTTA, M
    YAMAUCHI, N
    DEMURA, H
    SHIZUME, K
    WAKABAYASHI, I
    LING, N
    ENDOCRINOLOGY, 1986, 118 (06) : 2390 - 2394
  • [45] Chronic elevation in plasma free fatty acids impairs insulin secretion in non-diabetic offspring with a strong family history of T2DM
    Kashyap, S
    Belfort, R
    Pratipanawatr, T
    Berria, R
    Pratipanawatr, W
    Bajaj, M
    Mandarino, L
    Defronzo, R
    Cusi, K
    DIABETES, 2002, 51 : A12 - A13
  • [46] EFFECT OF FREE FATTY-ACIDS ON INSULIN-RECEPTOR BINDING AND TYROSINE KINASE-ACTIVITY IN HEPATOCYTES ISOLATED FROM LEAN AND OBESE RATS
    SVEDBERG, J
    BJORNTORP, P
    SMITH, U
    LONNROTH, P
    DIABETES, 1992, 41 (03) : 294 - 298
  • [47] Chronic exposure to high glucose or free fatty acids impairs insulin secretion by incresing uncoupling-2 protein (UCP-2) expression and affecting glucose metabolism.
    Patané, G
    Anello, M
    Piro, S
    Vigneri, R
    Purrello, F
    Rabuazzo, AM
    DIABETOLOGIA, 2001, 44 : A140 - +
  • [48] Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene
    Stefan, N
    Fritsche, A
    Häring, H
    Stumvoll, M
    DIABETES, 2001, 50 (05) : 1143 - 1148
  • [50] Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada - A population at very high risk for developing type 2 diabetes
    Carpentier, A
    Zinman, B
    Leung, N
    Giacca, A
    Hanley, AJG
    Harris, SB
    Hegele, RA
    Lewis, GF
    DIABETES, 2003, 52 (06) : 1485 - 1495