NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system

被引：25

作者：

French, Caitlin D. ^{[1
]}

Willoughby, Rodney E. ^{[2
]}

Pan, Amy ^{[2
]}

Wong, Susan J. ^{[3
]}

Foley, John F. ^{[4
]}

Wheat, L. Joseph ^{[5
]}

Fernandez, Josefina ^{[6
]}

Encarnacion, Rafael ^{[6
]}

Ondrush, Joanne M. ^{[7
]}

Fatteh, Naaz ^{[7
]}

Paez, Andres ^{[8
]}

David, Dan ^{[9
]}

Javaid, Waleed ^{[10
]}

Amzuta, Ioana G. ^{[10
]}

Neilan, Anne M. ^{[11
]}

Robbins, Gregory K. ^{[11
]}

Brunner, Andrew M. ^{[11
]}

Hu, William T. ^{[12
]}

Mishchuk, Darya O. ^{[13
]}

Slupsky, Carolyn M. ^{[1
,13
]}

机构：

[1] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA

[2] Med Coll Wisconsin, Dept Pediat, Div Infect Dis, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA

[3] New York State Dept Hlth, Wadsworth Ctr Diagnost Immunol Lab, Albany, NY USA

[4] Intermt Healthcare, Salt Lake City, UT USA

[5] Indiana Univ Sch Med, Dept Med, Div Infect Dis, Indianapolis, IN 46202 USA

[6] Hosp Infantil Robert Reid Cabral, Santo Domingo, Distrito Nacion, Dominican Rep

[7] Inova Fairfax Hosp, Fairfax, VA USA

[8] Univ Salle, Dept Ciencias Basicas, Bogota, Colombia

[9] Kimron Vet Inst, Rabies Lab, Bet Dagan, Israel

[10] SUNY Upstate Med Univ, Dept Med, Syracuse, NY 13210 USA

[11] Massachusetts Gen Hosp, Dept Med, Div Infect Dis, Boston, MA 02114 USA

[12] Mayo Clin, Rochester, MN USA

[13] Univ Calif Davis, Dept Food Sci & Technol, Davis, CA 95616 USA

来源：

PLOS NEGLECTED TROPICAL DISEASES | 2018年 / 12卷 / 12期

基金：

美国食品与农业研究所;

关键词：

CONSENSUS GUIDELINES; PARKINSONS-DISEASE; ENCEPHALITIS; ACID; METABONOMICS; MENINGITIS; BIOMARKERS; MANAGEMENT; DIAGNOSIS; CHILDREN;

D O I：

10.1371/journal.pntd.0007045

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background Myriad infectious and noninfectious causes of encephalomyelitis (EM) have similar clinical manifestations, presenting serious challenges to diagnosis and treatment. Metabolomics of cerebrospinal fluid (CSF) was explored as a method of differentiating among neurological diseases causing EM using a single CSF sample. Methodology/Principal findings H-1 NMR metabolomics was applied to CSF samples from 27 patients with a laboratory-confirmed disease, including Lyme disease or West Nile Virus meningoencephalitis, multiple sclerosis, rabies, or Histoplasma meningitis, and 25 controls. Cluster analyses distinguished samples by infection status and moderately by pathogen, with shared and differentiating metabolite patterns observed among diseases. CART analysis predicted infection status with 100% sensitivity and 93% specificity. Conclusions/Significance These preliminary results suggest the potential utility of CSF metabolomics as a rapid screening test to enhance diagnostic accuracies and improve patient outcomes.

引用

页数：17

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