(1S,3R,4R)-2-azanorbornyl-3-methanol oxazaborolidines in the asymmetric reduction of ketones

被引：35

作者：

Pinho, P ^{[1
]}

Guijarro, D ^{[1
]}

Andersson, PG ^{[1
]}

机构：

[1] Univ Uppsala, Dept Organ Chem, S-75121 Uppsala, Sweden

来源：

TETRAHEDRON | 1998年 / 54卷 / 27期

关键词：

asymmetric reactions; reduction; ketones; amino alcohols;

D O I：

10.1016/S0040-4020(98)00424-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of new rigid (1S, 3R, 4R)-2-azanorbornyl-3-methanols and its application in the asymmetric borane reduction of ketones are described. The influence of temperature, solvent and concentration on the reaction outcome were also studied and enantiomeric excess up to 89% could be obtained. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7897 / 7906

页数：10

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