Nitric oxide donor ß2-agonists:: Furoxan derivatives containing the fenoterol moiety and related furazans

被引：23
|
作者：
Buonsanti, M. Federica [1 ]
Bertinaria, Massimo [1 ]
Di Stilo, Antonella [1 ]
Cena, Clara [1 ]
Fruttero, Roberta [1 ]
Gasco, Alberto [1 ]
机构：
[1] Univ Turin, Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 50卷 / 20期
关键词：
D O I：
10.1021/jm0704595
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The structure of fenoterol, ss(2)-adrenoceptor agonist used in therapy, has been joined with furoxan NO-donor moieties to give new NO-donor ss(2)-agonists. The furazan analogues, devoid of the property to release NO, were also synthesized for comparison. All the compounds retained ss(2)-agonistic activity at micromolar or submicromolar concentration when tested on guinea pig tracheal rings precontracted with carbachol. Among the furoxan derivatives, the NO contribution to trachea relaxation was evident with product 15b at micromolar concentrations. All the new NO-donor hybrids were able to dilate rat aortic strips precontracted with phenylephrine. Both furoxan and furazan derivatives displayed antioxidant activity greater than that of fenoterol.
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收藏
页码：5003 / 5011
页数：9
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