Facile enantiodivergent approach to 5-hydroxy-5,6-dihydro-2(1H)-pyridones.: First total synthesis of both enantiomers of pipermethystine

被引：33

作者：

Arrayás, RG ^{[1
]}

Alcudia, A ^{[1
]}

Liebeskind, LS ^{[1
]}

机构：

[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 21期

关键词：

D O I：

10.1021/ol010183+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A novel enantiodivergent approach to 5-hydroxy-5,6-dihydro-2(lh)-pyridones using a ring closing metathesis and a lipase-mediated kinetic resolution as key steps is described and applied to the first synthesis of both enantiomers of pipermethystine.

引用

页码：3381 / 3383

页数：3

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