A Paterno-Buchi approach to the synthesis of merrilactone A

被引：43
|
作者：
Iriondo-Alberdi, J [1 ]
Perea-Buceta, JE [1 ]
Greaney, MF [1 ]
机构：
[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 18期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1021/ol0514496
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A six-step approach to the tetracyclic core of merrilactone A is described that uses an intramolecular Paterno-BUchi photoaddition to install the key oxetane ring. Irradiation of bicyclic enone 16, constructed through cyclopentenone alkylation followed by a domino oxy-/carbopalladation reaction, produces the tetracyclic oxetane 17 in excellent yield, having the core carbon skeleton of the target compound merrilactone A.
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页码：3969 / 3971
页数：3
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