Curcumin-induced cell death in two leukemia cell lines: K562 and Jurkat

被引：40
|
作者：
Duvoix, A
Morceau, F
Schnekenburger, M
Delhalle, S
Galteau, MM
Dicato, M
Diederich, M
机构：
[1] Ctr Univ Luxembourg, Lab RCMS, L-1511 Luxembourg, Luxembourg
[2] Univ Nancy 1, Fac Pharm, Lab Thiols & Fonct Cellulaires, F-54000 Nancy, France
来源：
APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷
关键词：
curcumin; leukemia; apoptosis;
D O I：
10.1196/annals.1299.071
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Curcumin presents strong antioxidant and anticancer properties. However, molecular mechanisms leading to curcumin-induced cell death are poorly understood. The effect of curcumin was compared in two different leukemia cell lines: K562 and Jurkat. Cell death was induced in both cell lines, and apoptosis pathways were investigated by Western blot analysis. Decreases in pro-caspase 8 and 9 levels were observed. BH3 interacting domain death agonist (Bid) was also cleaved. Jurkat cells appeared to be more sensitive to curcumin, and apoptosis takes place earlier.
引用
收藏
页码：389 / 392
页数：4
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