Role of the innate immune system in the development of chronic colitis

被引：16

作者：

Kanai, T ^{[1
]}

Iiyama, R ^{[1
]}

Ishikura, T ^{[1
]}

Uraushihara, K ^{[1
]}

Totsuka, T ^{[1
]}

Yamazaki, M ^{[1
]}

Nakamuma, T ^{[1
]}

Watanabe, M ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch, Dept Gastroenterol & Hepatol, Bunkyo Ku, Tokyo 1138519, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2002年 / 37卷 / Suppl 14期

关键词：

Peyer's patch; innate immunity; toll-like receptor; MyD88; inflammatory bowel disease;

D O I：

10.1007/BF03326411

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD).

引用

页码：38 / 42

页数：5

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