The Good, The Bad, and The Unexpected: Roles of DUX4 in Health and Disease

被引：4
|
作者：
Himeda, Charis L. [1 ]
Jones, Peter L. [1 ]
机构：
[1] Univ Nevada, Reno Sch Med, Dept Pharmacol, Reno, NV 89557 USA
来源：
DEVELOPMENTAL CELL | 2019年 / 50卷 / 05期
关键词：
GENES;
D O I：
10.1016/j.devcel.2019.08.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this issue of Developmental Cell, Chew et al. (2019) show that the pioneer factor DUX4 is misexpressed in tumors, where it suppresses anti-tumor immune activity. Their findings provide a new mechanism for immune evasion in cancer and highlight the pathogenic effects of re-expressing an embryonic program in adult cells.
引用
收藏
页码：525 / 526
页数：2
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