In this study, a new superconducting quantum interference device (SQUID) biomagnetic measurement system known as magnetospinogram (MSG) is developed. The MSG system is used for observation of a weak magnetic field distribution induced by the neural activity of the spinal cord over the body surface. The current source reconstruction for the observed magnetic field distribution provides noninvasive functional imaging of the spinal cord, which enables medical personnel to diagnose spinal cord diseases more accurately. The MSG system is equipped with a uniquely shaped cryostat and a sensor array of vector-type SQUID gradiometers that are designed to detect the magnetic field from deep sources across a narrow observation area over the body surface of supine subjects. The latest prototype of the MSG system is already applied in clinical studies to develop a diagnosis protocol for spinal cord diseases. Advancements in hardware and software for MSG signal processing and cryogenic components aid in effectively suppressing external magnetic field noise and reducing the cost of liquid helium that act as barriers with respect to the introduction of the MSG system to hospitals. The application of the MSG system is extended to various biomagnetic applications in addition to spinal cord functional imaging given the advantages of the MSG system for investigating deep sources. The study also includes a report on the recent advancements of the SQUID MSG system including its peripheral technologies and wide-spread applications.
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The Citadel, Dept Elect & Comp Engn, Mil Coll South Carolina, Charleston, SC 29409 USAThe Citadel, Dept Elect & Comp Engn, Mil Coll South Carolina, Charleston, SC 29409 USA
Mazzaro, Gregory J.
Martone, Anthony F.
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US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USAThe Citadel, Dept Elect & Comp Engn, Mil Coll South Carolina, Charleston, SC 29409 USA
Martone, Anthony F.
Ranney, Kenneth I.
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US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USAThe Citadel, Dept Elect & Comp Engn, Mil Coll South Carolina, Charleston, SC 29409 USA
Ranney, Kenneth I.
Narayanan, Ram M.
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Penn State Univ, Dept Elect Engn & Comp Sci, State Coll, PA 16801 USAThe Citadel, Dept Elect & Comp Engn, Mil Coll South Carolina, Charleston, SC 29409 USA
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Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, SingaporeNanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
Zhang, Huacheng
Gruener, George
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Univ Calif Los Angeles, Dept Phys & Astron, Los Angeles, CA 90095 USA
King Abdulaziz Univ, Fac Sci, Dept Chem, Ctr Excellence Adv Mat Res, Jeddah 21598, Saudi ArabiaNanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
Gruener, George
Zhao, Yanli
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Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, SingaporeNanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
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Northeastern Univ, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA 02115 USANortheastern Univ, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA 02115 USA
Pan, Jiayi
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Yalamarty, Satya Siva Kishan
Torchilin, Vladimir P.
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Northeastern Univ, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA 02115 USA
IM Sechenov First Moscow State Med Univ, Sechenov Univ, Dept Oncol Radiotherapy & Plast Surg, Moscow, RussiaNortheastern Univ, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA 02115 USA
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Karnataka Inst Med Sci KIMS, Dept Anaesthesiol, Hubli, Karnataka, IndiaKarnataka Inst Med Sci KIMS, Dept Anaesthesiol, Hubli, Karnataka, India
Kurdi, Madhuri S.
Agrawal, Pushpa
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Dr Vaishampayan Mem Govt Med Coll, Dept Anaesthesiol, Solapur, Maharashtra, IndiaKarnataka Inst Med Sci KIMS, Dept Anaesthesiol, Hubli, Karnataka, India
Agrawal, Pushpa
Thakkar, Parna
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Sir HN Reliance Fdn Hosp, Dept Anaesthesia, Mumbai, Maharashtra, IndiaKarnataka Inst Med Sci KIMS, Dept Anaesthesiol, Hubli, Karnataka, India
Thakkar, Parna
Arora, Divesh
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Asian Hosp, Dept Anaesthesia, Faridabad, Haryana, IndiaKarnataka Inst Med Sci KIMS, Dept Anaesthesiol, Hubli, Karnataka, India
Arora, Divesh
Barde, Saurabh M.
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RNH Hosp, Dept Anaesthesia, Nagpur, Maharashtra, IndiaKarnataka Inst Med Sci KIMS, Dept Anaesthesiol, Hubli, Karnataka, India
Barde, Saurabh M.
Eswaran, Kala
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JK Womens Hosp, Manav Kalyan Kendra, Dept Anaesthesiol, Dombivli, Maharashtra, IndiaKarnataka Inst Med Sci KIMS, Dept Anaesthesiol, Hubli, Karnataka, India