Road blocks in making platelets for transfusion

被引：28
|
作者：
Thon, J. N. [1 ,2 ,3 ]
Medvetz, D. A. [1 ,2 ]
Karlsson, S. M. [3 ]
Italiano, J. E., Jr. [1 ,2 ,3 ]
机构：
[1] Brigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Platelet BioGenesis, Chestnut Hill, MA USA
来源：
JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2015年 / 13卷
关键词：
biomedical engineering; bioreactors; hematopoietic stem cells; megakaryocytes; platelets; EMBRYONIC STEM-CELLS; IN-VITRO; EX-VIVO; FUNCTIONAL PLATELETS; HUMAN MEGAKARYOCYTES; PERIPHERAL-BLOOD; SYSTEMS BIOLOGY; CORD BLOOD; MOUSE; GENERATION;
D O I：
10.1111/jth.12942
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The production of laboratory-generated human platelets is necessary to meet present and future transfusion needs. This manuscript will identify and define the major roadblocks that must be overcome to make human platelet production possible for clinical use, and propose solutions necessary to accelerate development of laboratory-generated human platelets to market.
引用
收藏
页码：S55 / S62
页数：8
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