DBS for Obesity

被引：18

作者：

Franco, Ruth ^{[1
]}

Fonoff, Erich T. ^{[2
]}

Alvarenga, Pedro ^{[3
]}

Lopes, Antonio Carlos ^{[3
]}

Miguel, Euripides C. ^{[3
]}

Teixeira, Manoel J. ^{[2
]}

Damiani, Durval ^{[1
]}

Hamani, Clement ^{[2
,4
,5
]}

机构：

[1] Univ Sao Paulo, Sch Med, Childrens Hosp, Div Pediat Endocrinol, BR-05403000 Sao Paulo, Brazil

[2] Univ Sao Paulo, Sch Med, Inst Psychiat, Div Funct Neurosurg,Dept Neurol, BR-01060970 Sao Paulo, Brazil

[3] Univ Sao Paulo, Sch Med, Inst Psychiat, Dept Psychiat, BR-01060970 Sao Paulo, Brazil

[4] Univ Toronto, Toronto Western Hosp, Div Neurosurg, Toronto, ON M5T 1R8, Canada

[5] Ctr Addict & Mental Hlth, Div Neuroimaging, Toronto, ON M5T 1R8, Canada

来源：

BRAIN SCIENCES | 2016年 / 6卷 / 03期

关键词：

deep brain stimulation; obesity; hypothalamus; nucleus accumbens; DEEP BRAIN-STIMULATION; LATERAL HYPOTHALAMIC AREA; PRADER-WILLI-SYNDROME; FOOD-INTAKE; VENTROMEDIAL HYPOTHALAMUS; BODY-WEIGHT; ELECTRICAL-STIMULATION; SATIATED RATS; DOPAMINE; NUCLEUS;

D O I：

10.3390/brainsci6030021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Obesity is a chronic, progressive and prevalent disorder. Morbid obesity, in particular, is associated with numerous comorbidities and early mortality. In patients with morbid obesity, pharmacological and behavioral approaches often have limited results. Bariatric surgery is quite effective but is associated with operative failures and a non-negligible incidence of side effects. In the last decades, deep brain stimulation (DBS) has been investigated as a neurosurgical modality to treat various neuropsychiatric disorders. In this article we review the rationale for selecting different brain targets, surgical results and future perspectives for the use of DBS in medically refractory obesity.

引用

页数：9

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