An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction

被引：0

作者：

Zolfigol, Mohammad Ali ^{[1
]}

Khazaei, Ardeshir ^{[1
]}

Moosavi-Zare, Ahmad Reza ^{[1
]}

Zare, Abdolkarim ^{[2
]}

Hasanijejad, Ali Reza ^{[3
]}

机构：

[1] Bu Ali Sina Univ, Fac Chem, Hamadan, Iran

[2] PNU, Dept Chem, Tehran, Iran

[3] Persian Gulf Univ, Fac Sci, Dept Chem, Bushehr, Iran

来源：

IRANIAN JOURNAL OF CHEMISTRY & CHEMICAL ENGINEERING-INTERNATIONAL ENGLISH EDITION | 2010年 / 29卷 / 04期

关键词：

Carboacyclic nucleoside; Aza-conjugate addition reaction; Pyrimidine nucleobase; alpha; beta-unsaturated ester; Microwave; MICHAEL ADDITION; ALPHA; BETA-UNSATURATED ESTERS; PURINE NUCLEOBASES; HIGHLY EFFICIENT; PYRIMIDINE; CATALYST; GREEN; DERIVATIVES; SOLVENT;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new efficient method for the synthesis of carboacyclic nucleosides as biologically interesting compounds via aza-conjugate addition of pyrimidine nucleobases to alpha,beta-unsaturated esters in the presence of catalytic amount of LiOH center dot H2O (1.2-4.8 mol%) under microwave irradiation is described. This method affords the title compounds in good to excellent yields and in short reaction times. [GRAPHICS]

引用

页码：67 / 73

页数：7

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