Synthesis and Antibacterial Activity of N-Substituted 2-(Benzylimino)-4-styryl-2,5-dihydrofuran-3-carboxamides

被引：0
|
作者：
Karapetyan, L., V [1 ]
Tokmajyan, G. G. [1 ]
Stepanyan, H. M. [2 ]
机构：
[1] Yerevan State Univ, Yerevan 0025, Armenia
[2] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 57卷 / 12期
关键词：
functionally substituted 2-imino-2; 5-dihydrofurans; benzylamine; 2-benzylimino-4-styryl-2; glacial acetic acid; antibacterial activity; 2-IMINO-2,5-DIHYDROFURAN-3-CARBOXAMIDES; DERIVATIVES; SYSTEMS;
D O I：
10.1134/S1070428021120113
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Previously unknown N-substituted 2-(benzylimino)-4-styryl-2,5-dihydrofuran-3-carboxamides were synthesized by reaction of 2-imino-2,5-dihydrofuran-3-carboxamides with benzylamine in glacial acetic acid. It was found that a part of benzylamine reacts as a nucleophile at the imino group and that the other part undergoes oxidation followed by dehydration to generate benzylimine which acts as a synthetic equivalent of benzaldehyde toward the 4-methyl group. The synthesized compounds were characterized by IR and NMR spectra and elemental analyses. 2-(Benzylimino)-N,5,5-trimethyl-4-(2-phenylethenyl)-2,5-dihydrofuran-3-carboxamide was also synthesized independently by reaction of previously reported 2-imino-4-(2-phenylethenyl)-N,5,5-trimethyl-2,5-dihydrofuran-3-carboxamide with benzylamine in glacial acetic acid.
引用
收藏
页码：1974 / 1978
页数：5
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