Plasma Neutralization of the SARS-CoV-2 Omicron Variant

被引：305

作者：

Schmidt, Fabian ^{[1
]}

Muecksch, Frauke ^{[1
]}

Weisblum, Yiska ^{[1
]}

Da Silva, Justin ^{[1
]}

Bednarski, Eva ^{[1
]}

Cho, Alice ^{[1
]}

Wang, Zijun ^{[1
]}

Gaebler, Christian ^{[1
]}

Caskey, Marina ^{[1
]}

Nussenzweig, Michel C. ^{[1
]}

Hatziioannou, Theodora ^{[1
]}

Bieniasz, Paul D. ^{[1
]}

机构：

[1] Rockefeller Univ, 1230 York Ave, New York, NY 10021 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2022年 / 386卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1056/NEJMc2119641

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Omicron Neutralization after the Third Vaccine Dose Neutralization assays of SARS-CoV-2 pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in plasma drawn from 47 people over time showed much lower omicron neutralization than Wuhan-hu-1 neutralization after two doses of an mRNA vaccine. However, samples from persons vaccinated after recovery from Covid-19 and those who received a booster vaccine had high levels of omicron neutralization.

引用

页码：599 / 601

页数：4

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