MiR-145: a potential biomarker of cancer migration and invasion

被引：16

作者：

Xu, Wen-Xiu ^{[1
,2
]}

Liu, Zhen ^{[1
,2
]}

Deng, Fei ^{[1
,2
]}

Wang, Dan-Dan ^{[1
]}

Li, Xing-Wang ^{[3
]}

Tian, Tian ^{[3
]}

Zhang, Jian ^{[1
]}

Tang, Jin-Hai ^{[1
,2
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Gen Surg, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Clin Sch 1, Nanjing 210029, Jiangsu, Peoples R China

[3] Xuzhou Med Univ, Sch Clin Med, 209 Tongshan Rd, Xuzhou 221004, Jiangsu, Peoples R China

来源：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2019年 / 11卷 / 11期

基金：

中国国家自然科学基金;

关键词：

MiR-145; cancers; biomarker; invasion and migration; LONG NONCODING RNA; ENDOTHELIAL GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; INHIBITS TUMOR-GROWTH; SUPPRESSES CELL INVASION; COLORECTAL-CANCER; MICRORNA-145; TARGETS; PROSTATE-CANCER; GASTRIC-CANCER; DNA HYPERMETHYLATION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MircoRNAs (miRNAs) are a diverse family of highly conserved small non-coding RNAs, which range from approximately 18 to 25 nucleotides in size. They regulate gene expression transcriptionally or post-transcriptionally via binding to the 3'-untranslated region (3'-UTR) of target message RNAs (mRNAs). MiRNAs have emerged as molecular regulators that participate in physiological and pathological processes of diverse malignancies. Among them, miRNA-145 (miR-145) played a profound role in tumorigenesis and progression of various neoplasms. In this review, we summarized the recent findings regarding miR-145, to elucidate its functional roles in cell invasion and migration of diverse human malignancies, and considered it a potential biomarker for cancer diagnosis, screening, and prognosis.

引用

页码：6739 / 6753

页数：15

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