Domino [Pd]-Catalysis: One-Pot Synthesis of Isobenzofuran-1 (3H)-ones

被引：45

作者：

Mahendar, Lodi ^{[1
]}

Satyanarayana, Gedu ^{[1
]}

机构：

[1] Indian Inst Technol Hyderabad, Dept Chem, Sangareddy 502285, Telangana, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 17期

关键词：

CATALYZED CARBONYLATIVE SYNTHESIS; DIELS-ALDER REACTION; THALLATION-CARBONYLATION; MYCOPHENOLIC-ACID; ARYL HALIDES; PALLADIUM; CO; ALDEHYDES; PHTHALIDES; CYCLIZATION;

D O I：

10.1021/acs.joc.6b01396

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient domino [Pd]-catalysis for the synthesis of isobenzofuran-1(3H)-ones is presented. The strategy shows broad substrate scope and is amenable to o-bromobenzyl tertiary/secondary/primary alcohols. Significantly, the method was applied to the synthesis of antiplatelet drug n-butyl phthalide and cytotoxic agonist 3a-[4'-methoxylbenzyl]-5,7-dimethoxyphthalide.

引用

页码：7685 / 7691

页数：7

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