Negative regulation of insulin signaling by PTEN/MMAC1 in 3T3-L1 adipocytes

被引：0

作者：

Nakashima, N ^{[1
]}

Olefsky, JM ^{[1
]}

Umeda, F ^{[1
]}

Nawata, H ^{[1
]}

机构：

[1] Nakatsu Natl Hosp, Dept Internal Med, Nakatsu City 8710024, Japan

来源：

DIABETES MELLITUS: RECENT ADVANCES FOR THE 21ST CENTURY | 2000年 / 1209卷

关键词：

lipid phosphatase; PIP3; PI3-kinase; glucose transport; GLUT; 1;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. PTEN is capable of dephosphorylating PI(3,4,5)P-3 in vitro and down-regulating its levels in insulin-stimulated 293 cells. We found that PTEN acts as a negative regulator of insulin signaling pathway in 3T3 L1 adipocytes, and that GLUT I translocation is actually dependent on the balance between PI3-kinase and PTEN activity, although PTEN's physiological role is still unknown.

引用

页码：169 / 172

页数：4

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