Synthesis and in vitro antitumor activity of some tetraphenylantimony derivatives of exo-7-oxa-bicyclo[2,2,1] heptane (ene)-3-arylamide-2-acid

被引：40
|
作者：
Li, JS [1 ]
Ma, YQ
Cui, JR
Wang, RQ
机构：
[1] Nankai Univ, Natl Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
[2] Peking Univ, Natl Res Labs Nat & Biomimet Drugs, Beijing 100083, Peoples R China
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2001年 / 15卷 / 07期
关键词：
antimony; crystal structure; antitumor activity;
D O I：
10.1002/aoc.200
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A series of novel tetraphenylantimony derivatives of exo-7-oxa-bicyclo[2,2,1] heptane (ene)-3-arylamide-2-acid of the general formula Ph4SbO2CCHCHCH2CH2CH(O)CHCONHAr (Ar = Ph,4-ClC6H4, 4-BrC6H4, 3-BrC6H4, 4-F-3-ClC6H3 and 4-MeC6H4) have been synthesized and characterized by elemental analysis, IR, H-1 NMR and mass spectra. The crystal structure of Ph4SbO2CCHCHCH2CH2CH(O)CHCONHC6 H4CH3. CHCl3 was determined by X-ray diffraction, Five human neoplastic cell lines (HL-60, KB, Bel-7402, BGC-823 and HCT-8) were used to screen these compounds. The results indicate that these compounds at 10 muM show certain in vitro antitumor activities. Copyright (C) 2001 John Wiley & Sons, Ltd.
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页码：639 / 645
页数：7
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