Biaryl Formation via Base-Promoted Direct Coupling Reactions of Arenes with Aryl Halides

被引：10
|
作者：
Iqbal, Muhammad Asif [1 ]
Lu, Le [1 ]
Mehmood, Hina [1 ]
Hua, Ruimao [1 ]
机构：
[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China
来源：
ACS OMEGA | 2021年 / 6卷 / 24期
基金：
中国国家自然科学基金;
关键词：
C-H ARYLATION; BOND FORMATION;
D O I：
10.1021/acsomega.1c01736
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the absence of ligand, Cs2CO3-promoted cross-coupling reaction of arenes with cyano-/nitro-substituted aryl halides in DMSO affording biaryls is reported. The cyano/nitro group in biaryls is useful and convenient for further transformation. The formation of dibenzofurans resulting from the reactions between arenes and 1-bromo-2-iodobenzene is also reported. On the basis of control experiments and theoretical studies, a radical mechanism is proposed for the formation of biaryls.
引用
收藏
页码：15981 / 15987
页数：7
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