All-optical phase modulation for integrated interferometric biosensors

被引：76
|
作者：
Dante, Stefania [1 ,2 ]
Duval, Daphne [1 ,2 ]
Sepulveda, Borja [1 ,2 ]
Belen Gonzalez-Guerrero, Ana [1 ,2 ]
Ramon Sendra, Jose [3 ]
Lechuga, Laura M. [1 ,2 ]
机构：
[1] Res Ctr Nanosci & Nanotechnol CIN2 CSIC, Barcelona 08193, Spain
[2] CIBER BBN, Barcelona 08193, Spain
[3] Univ La Palmas GC, IUMA, Inst Appl Microelect, Las Palmas Gran Canaria, Spain
来源：
OPTICS EXPRESS | 2012年 / 20卷 / 07期
关键词：
WAVE-GUIDE; LIQUID;
D O I：
10.1364/OE.20.007195
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We present the theoretical and the experimental implementation of an all-optical phase modulation system in integrated Mach-Zehnder Interferometers to solve the drawbacks related to the periodic nature of the interferometric signal. Sensor phase is tuned by modulating the emission wavelength of low-cost commercial laser diodes by changing their output power. FFT deconvolution of the signal allows for direct phase readout, immune to sensitivity variations and to light intensity fluctuations. This simple phase modulation scheme increases the signal-to-noise ratio of the measurements in one order of magnitude, rendering in a sensor with a detection limit of 1.9. 10(-7) RIU. The viability of the all-optical modulation approach is demonstrated with an immunoassay detection as a biosensing proof of concept. (C) 2012 Optical Society of America
引用
收藏
页码：7195 / 7205
页数：11
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