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Desmin expression profile in reactive astrocytes in the 3-nitropropionic acid lesioned striatum of rat: Characterization and comparison with glial fibrillary acidic protein and nestin
被引:14
|作者:
Choi, Jeong-Heon
[1
,2
]
Riew, Tae-Ryong
[1
,2
]
Kim, Hong Lim
[3
]
Jin, Xuyan
[1
,2
]
Lee, Mun-Yong
[1
,2
]
机构:
[1] Catholic Univ Korea, Coll Med, Catholic Neurosci Inst, Cell Death Dis Res Ctr, Seoul, South Korea
[2] Catholic Univ Korea, Coll Med, Dept Anat, 222 Banpo Daero, Seoul 06501, South Korea
[3] Catholic Univ Korea, Coll Med, Electron Microscopy Lab, Integrat Res Support Ctr, Seoul, South Korea
基金:
新加坡国家研究基金会;
关键词:
Desmin;
Glial fibrillary acidic protein;
Nestin;
Reactive astrocytes;
Glial scar;
INTERMEDIATE-FILAMENT PROTEIN;
HEPATIC STELLATE CELLS;
MUSCLE;
MODEL;
DISEASES;
SYSTEM;
TISSUE;
LIVER;
D O I:
10.1016/j.acthis.2017.10.003
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Desmin, a muscle-specific, type-III intermediate-filament protein, is reportedly expressed in astrocytes in the central nervous system. These cells become reactive astrocytes in response to brain injuries. To elucidate whether desmin is involved in this process, we examined the spatiotemporal expression profiles of desmin and their relationship with two astroglial intermediate filaments, glial fibrillary acidic protein (GFAP) and nestin, in the striatum of rats treated with the mitochondrial toxin 3-nitropropionic acid (3-NP). Weak, constitutive immunoreactivity for desmin was observed in astrocytes generally, and in reactive astrocytes in the peri-lesional area, its expression increased in parallel with that of GFAP over 3 d post-lesion and was maintained until at least day 28. Desmin, GFAP, and nestin showed characteristic time-dependent expression patterns in reactive astrocytes forming the astroglial scar; delayed and long-lasting induction of desmin and GFAP, and rapid but transient induction of nestin. In the lesion core, desmin was expressed in two categories of perivascular cells: nestinnegative and nestin-positive. These findings show that desmin, together with GFAP and nestin, is a dynamic component of intermediate filaments in activated astroglia, which may account for the dynamic structural changes seen in these cells in response to brain injuries.
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页码:795 / 803
页数:9
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