Ultrasound responsive mesoporous silica nanoparticles for biomedical applications

被引：73

作者：

Manzano, Miguel ^{[1
,2
]}

Vallet-Regi, Maria ^{[1
,2
]}

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Quim Ciencias Farmaceut, Inst Invest Sanitaria Hosp 12 Octubre I 12, Plaza Ramon y Cajal S-N, E-28040 Madrid, Spain

[2] CIBER BBN, Madrid, Spain

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 19期

基金：

欧洲研究理事会;

关键词：

MESENCHYMAL STEM-CELLS; CONTROLLED DRUG-RELEASE; CAVITATION-ENHANCED EXTRAVASATION; TARGETED-DELIVERY VEHICLE; ORGANIC-INORGANIC HYBRID; BLOOD-BRAIN-BARRIER; FOCUSED ULTRASOUND; TRIGGERED RELEASE; IN-VITRO; ANTICANCER DRUG;

D O I：

10.1039/c8cc09389j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanotechnology, which has already revolutionised many technological areas, is expected to transform life sciences. In this sense, nanomedicine could address some of the most important limitations of conventional medicine. In general, nanomedicine includes three major objectives: (1) trap and protect a great amount of therapeutic agents; (2) carry them to the specific site of disease avoiding any leakage; and (3) release on-demand high local concentrations of therapeutic agents. This feature article will make special emphasis on mesoporous silica nanoparticles that release their therapeutic cargo in response to ultrasound.

引用

页码：2731 / 2740

页数：10

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