Spectroscopic and crystallographic characterization of two cathinone derivatives: 1-(4-fluorophenyl)-2-(methylamino)pentan-1-one (4-FPD) hydrochloride and 1-(4-methylphenyl)-2-(ethylamino)pentan-1-one (4-MEAP) hydrochloride

被引：12
|
作者：
Rojkiewicz, Marcin [1 ]
Kus, Piotr [1 ]
Kusz, Joachim [2 ]
Ksiazek, Maria [2 ]
机构：
[1] Univ Silesia, Inst Chem, Dept Organ Synth, 9 Szkolna St, PL-40006 Katowice, Poland
[2] Univ Silesia, Inst Phys, Dept Crystal Phys, 4 Uniwersytecka St, PL-40007 Katowice, Poland
来源：
FORENSIC TOXICOLOGY | 2018年 / 36卷 / 01期
关键词：
4-FPD; 4-MEAP; Mass spectrometry; X-ray crystallography; Infrared and Raman spectroscopies; NMR spectroscopy; SYNTHETIC CATHINONES; BATH SALTS; DESIGNER CATHINONES; IDENTIFICATION; SPICE;
D O I：
10.1007/s11419-017-0393-6
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Purpose In this study, we performed identification and physicochemical characterization of two cathinone derivatives, 4-FPD and 4-MEAP, found in market-available materials. Methods The compounds were characterized by electrospray ionization ion trap mass spectrometry (MS) in MS2 and MS3 modes, gas chromatography-MS, infrared, Raman and ultraviolet-visible spectroscopies, X-ray crystallography, differential scanning calorimetry and nuclear magnetic resonance spectroscopy. Results We could obtain detailed and comprehensive physicochemical characterization of 4-FPD and 4-MEAP-new cathinone derivatives available on the designer drugs market. Conclusions Dynamic growth in the number of psychoactive substances available on the designer drug markets makes it compulsory to obtain analytical data allowing unequivocal identification of these drugs in the fastest possible way. In this study we presented analytical data useful in quick identification of the investigated compounds.
引用
收藏
页码：141 / 150
页数：10
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