Immunosuppressive and anti-inflammatory activities of sinomenine

被引：145

作者：

Wang, Quanxing ^{[2
,3
]}

Li, Xiao-Kang ^{[1
]}

机构：

[1] Natl Res Inst Child Hlth & Dev, Div Radiat Safety & Immune Tolerance, Setagaya Ku, Tokyo 1578535, Japan

[2] Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai, Peoples R China

[3] Second Mil Med Univ, Inst Immunol, Shanghai, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2011年 / 11卷 / 03期

关键词：

Autoimmune disease; Immunity; Lymphocyte; Antigen-presenting cells; Sinomenine; NF-KAPPA-B; ALKALOID SINOMENINE; DENDRITIC CELLS; RAT; EXPRESSION; MATURATION; APOPTOSIS; ACUTUM; PROLIFERATION; MACROPHAGES;

D O I：

10.1016/j.intimp.2010.11.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sinomenine (SN), a pure compound extracted from the Sinomenium acutum plant, has been found to inhibit T- and B-lymphocyte activation, proliferation and function and to interfere with the differentiation, recruitment and function of several other cell types, such as dendritic cells (DC). SN has demonstrated its potential anti-inflammatory role for treating immune-related disorders in experimental animal models and in some clinical applications. This review will summarize its potential effects, mechanisms and applications. Crown Copyright (c) 2010 Published by Elsevier B.V. All rights reserved.

引用

页码：373 / 376

页数：4

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