Tumour heterogeneity and metastasis at single-cell resolution

被引：408

作者：

Lawson, Devon A. ^{[1
,2
]}

Kessenbrock, Kai ^{[2
,3
]}

Davis, Ryan T. ^{[1
]}

Pervolarakis, Nicholas ^{[3
,4
]}

Werb, Zena ^{[5
,6
]}

机构：

[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92717 USA

[2] Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Irvine, CA 92697 USA

[3] Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92717 USA

[4] Univ Calif Irvine, Ctr Complex Biol Syst, Irvine, CA USA

[5] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Helen Diller Comprehens Canc Ctr, San Francisco, CA 94143 USA

来源：

NATURE CELL BIOLOGY | 2018年 / 20卷 / 12期

关键词：

NUCLEUS RNA-SEQ; SEQUENCING REVEALS; GENE-EXPRESSION; CHROMATIN ACCESSIBILITY; EARLY DISSEMINATION; INTRATUMOR HETEROGENEITY; GENOMIC ANALYSIS; MASS CYTOMETRY; IN-SITU; CANCER;

D O I：

10.1038/s41556-018-0236-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic properties that can differentially promote progression, metastasis and drug resistance. Emerging single-cell technologies provide a new opportunity to profile individual cells within tumours and investigate what roles they play in these processes. This Review discusses key technological considerations for single-cell studies in cancer, new findings using single-cell technologies and critical open questions for future applications.

引用

页码：1349 / 1360

页数：12

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