Tumour heterogeneity and metastasis at single-cell resolution

被引：408
|
作者：
Lawson, Devon A. [1 ,2 ]
Kessenbrock, Kai [2 ,3 ]
Davis, Ryan T. [1 ]
Pervolarakis, Nicholas [3 ,4 ]
Werb, Zena [5 ,6 ]
机构：
[1] Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92717 USA
[2] Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Irvine, CA 92697 USA
[3] Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92717 USA
[4] Univ Calif Irvine, Ctr Complex Biol Syst, Irvine, CA USA
[5] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
[6] Univ Calif San Francisco, Helen Diller Comprehens Canc Ctr, San Francisco, CA 94143 USA
来源：
NATURE CELL BIOLOGY | 2018年 / 20卷 / 12期
关键词：
NUCLEUS RNA-SEQ; SEQUENCING REVEALS; GENE-EXPRESSION; CHROMATIN ACCESSIBILITY; EARLY DISSEMINATION; INTRATUMOR HETEROGENEITY; GENOMIC ANALYSIS; MASS CYTOMETRY; IN-SITU; CANCER;
D O I：
10.1038/s41556-018-0236-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic properties that can differentially promote progression, metastasis and drug resistance. Emerging single-cell technologies provide a new opportunity to profile individual cells within tumours and investigate what roles they play in these processes. This Review discusses key technological considerations for single-cell studies in cancer, new findings using single-cell technologies and critical open questions for future applications.
引用
收藏
页码：1349 / 1360
页数：12
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