Immune signalling by supramolecular assemblies

被引：7
|
作者：
Kumar, Santosh [1 ]
Jain, Shweta [2 ,3 ,4 ]
机构：
[1] CSIR Ctr Cellular & Mol Biol, Uppal Rd, Hyderabad 500007, Telangana, India
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA
[3] Univ Calif San Francisco, Grad Program Neurosci, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Grad Program Biomed Sci, San Francisco, CA 94143 USA
来源：
IMMUNOLOGY | 2018年 / 155卷 / 04期
关键词：
absent in melanoma 2-like receptors; inflammasome; killer-cell immunoglobulin-like receptor; nucleotide-binding oligomerization domain-like receptors; retinoic acid-inducible gene-I-like receptors; signalosome; DOUBLE-STRANDED-RNA; NF-KAPPA-B; CELL-SURFACE RECEPTORS; NATURAL-KILLER-CELLS; RIG-I; STRUCTURAL BASIS; INNATE IMMUNITY; INFLAMMASOME ACTIVATION; PROTEIN AGGREGATION; PATTERN-RECOGNITION;
D O I：
10.1111/imm.12995
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Formation of supramolecular assemblies appears to be a general mechanism in immune signalling pathways. These supramolecular assemblies appear to form through a nucleated polymerization mechanism. This review examines selected immune signalling pathways that involve supramolecular assemblies, describes the concepts of protein polymerization, and discusses how those concepts of protein polymerization implicate new elegant ways for signal amplification, setting threshold and noise reduction in these pathways.
引用
收藏
页码：435 / 445
页数：11
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