Cloning and functional expression of the rat α2 subunit of soluble guanylyl cyclase

被引：21

作者：

Koglin, M ^{[1
]}

Behrends, S ^{[1
]}

机构：

[1] Univ Hamburg, Inst Expt & Klin Pharmakol, D-20251 Hamburg, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2000年 / 1494卷 / 03期

关键词：

soluble guanylyl cyclase; nitric oxide; enzyme isoform;

D O I：

10.1016/S0167-4781(00)00211-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide-sensitive guanylyl cyclase is a heterodimeric enzyme consisting of one alpha and one beta subunit. Here, we clone the first alpha (2) subunit ortholog and functionally express the cDNA in Sf-9 cells. Our data indicate a high degree of conservation of the primary sequence and functional activity of the rat at subunit. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：286 / 289

页数：4

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