Synthesis of X(Y)-(EO)n-OCH3 Type Heterobifunctional and X(Y)-(EO)n-Z Type Heterotrifunctional Poly(ethylene glycol)s

被引：7
|
作者：
Li, Zhongyu [1 ]
Chau, Ying [1 ]
机构：
[1] Hong Kong Univ Sci & Technol, Dept Chem & Biomol Engn, Clear Water Bay, Hong Kong, Peoples R China
来源：
BIOCONJUGATE CHEMISTRY | 2011年 / 22卷 / 03期
关键词：
ANIONIC-POLYMERIZATION; SELECTIVE SYNTHESIS; ORGANIC-SYNTHESIS; CLICK CHEMISTRY; ONE-POT; OXIDE); DERIVATIVES; CONJUGATION; PEGYLATION; COPOLYMER;
D O I：
10.1021/bc100417k
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A synthetic route to prepare acetal-protected heterobifunctional poly(othylene glycol), allyl(1-ethoxyethoxy)-PEG-OH (allyl(EE)-PEG-OH), was successfully established using a newly synthesized initiator, trimethylolpropane allyl (1-ethoxyethoxy) ether (TMPAEEE). Heterobifunctional allyl(OH)-mPEG and heterotrifunctional allyl(OH)-PEG-alkyne were obtained, respectively, after modification From this precursor polymer. The polymers were characterized by SEC, H-1 NMR, and MALDI-TOF mass spectroscopy. This approach is applicable for synthesizing a wide variety of X(Y)-(EO)(n)-OCH3 type heterobifunctional and X(Y)-(EO)(n)-Z type heterotrifunctional PEGs.
引用
收藏
页码：518 / 522
页数：5
相关论文
共 50 条
  • [21] Incorporation of fluorine into the N-type (AlxGayIn1-x-y)As system
    Hayafuji, N
    Yamamoto, Y
    Fujii, N
    Sonoda, T
    Takamiya, S
    OPTOELECTRONIC MATERIALS: ORDERING, COMPOSITION MODULATION, AND SELF-ASSEMBLED STRUCTURES, 1996, 417 : 415 - 420
  • [22] 关于不定方程（3n）x+（4n）y=（5n）z
    伊波
    孙丽梅
    高师理科学刊, 1999, (02) : 8 - 10
  • [23] SYNTHESIS, STRUCTURE AND PROPERTIES OF THE CHROMIUM NITROSYL COMPLEXES OF [CRNO(CN)X(EN)Y]N+/- TYPE
    KELLER, A
    JEZOWSKATRZEBIATOWSKA, B
    INORGANICA CHIMICA ACTA-ARTICLES, 1981, 51 (01): : 123 - 130
  • [24] POTENTIAL CONSTANTS AND THERMODYNAMIC PROPERTIES OF SOME X Y3 Z TYPE MOLECULES
    NAGARAJAN, G
    BULLETIN DES SOCIETES CHIMIQUES BELGES, 1961, 70 (11-2): : 758 - &
  • [25] Electrochemical characterization of a series of substituted Dawson type tungstophosphates α[P2W18-xMozVyO62]n- (x=y+z;n=6+y)
    Tommasino, JB
    Contant, R
    Michaut, JP
    Roncin, J
    POLYHEDRON, 1998, 17 (2-3) : 357 - 366
  • [26] On searching for solutions of the Diophantine equation x3 + y3 + z3 = n
    Koyama, K.
    Tsuruoka, Y.
    Sekigawa, H.
    Mathematics of Computation, 66 (218):
  • [27] On searching for solutions of the diophantine equation x3 + y3+2z3 = n
    Koyama, K
    MATHEMATICS OF COMPUTATION, 2000, 69 (232) : 1735 - 1742
  • [28] VALUES OF MESOMERIC MOMENTS OF R2N-X=Y-TYPE GROUPS
    PIGENET, C
    LUMBROSO, H
    BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1972, (10): : 3743 - &
  • [29] Interaction of halomethane CH3Z (Z = F, Cl, Br) with X12Y12 (X = B, Al, Ga & Y = N, P, As) nanocages
    Mohammadi, Mohsen Doust
    Abdullah, Hewa Y.
    Kalamse, Vijayanand G.
    Chaudhari, Ajay
    COMPUTATIONAL AND THEORETICAL CHEMISTRY, 2022, 1208
  • [30] Thermoelectric Properties of Heavily Doped n-type Pb1-x Y x Te Compounds
    Ruan, Limin
    Luo, Jun
    Zhu, Hangtian
    Zhao, Huaizhou
    Liang, Jingkui
    JOURNAL OF ELECTRONIC MATERIALS, 2015, 44 (10) : 3556 - 3562
12345