Pathophysiology of bone metastases in serologic carcinomas

被引：0
|
作者：
Sauer, G. [1 ]
Barth, T. F. E. [1 ]
Moeller, P. [1 ]
机构：
[1] Univ Ulm Klinikum, Inst Pathol, D-89081 Ulm, Germany
来源：
UROLOGE | 2007年 / 46卷 / 08期
关键词：
bone metastases; renal carcinoma; urothelial carcinoma; prostatic carcinoma;
D O I：
10.1007/s00120-007-1519-y
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The skeletal system is the most frequent metastatic site of hematogenous spread of urologic carcinomas. Osseus metastases are classified as osteoneutral, osteolytic, osteoblastic and combinations thereof. Osteolytic metastases lead to bone resorption by activating osteoclasts, while osteoblastic metastases stimulate osteoblasts by paracrine mechanisms. The local osteoblastic effect is associated with secondary systemic bone resorption. The use of bisphosphonates is now an established supportive therapy and newer treatment strategies including targeted intervention in the pathophysiology of bone metastases and radioimmunotherapy are being applied or will be coming soon.
引用
收藏
页码：888 / 890
页数：5
相关论文
共 50 条
  • [31] Suspiction of metastases in laryngeal carcinomas
    Esteban, F.
    Gonzalez-Perez, J. M.
    Benaixa, J. P.
    Gonzalez-Moles, M. A.
    Ruiz-Avila, I.
    Delgado-Rodriguez, M.
    Solano, J.
    ACTA OTORRINOLARINGOLOGICA ESPANOLA, 2005, 56 (10): : 477 - 481
  • [32] METASTASES AT A DISTANCE OF CARCINOMAS OF THE NASOPHARYNX
    ELLOUZ, R
    LADGHAM, A
    CAMMOUN, M
    JALLOULI, M
    ANTICANCER RESEARCH, 1982, 2 (06) : 323 - 323
  • [33] Metastases into renal cell carcinomas
    Caamano Villaverde, V.
    Schiavo-Lena, M.
    Yaguee, A.
    Zaldumbide, L.
    Guarch, R.
    Tardanico, R.
    Lopez, J. I.
    VIRCHOWS ARCHIV, 2013, 463 (02) : 331 - 332
  • [34] Occult metastases of supraglottic carcinomas
    Petrovic, Z
    Stefanovic, D
    Krejovic, B
    3RD EUROPEAN CONGRESS OF THE EUROPEAN FEDERATION OF OTO-RHINO-LARYNGOLOGICAL SOCIETIES - EUFOS, 1996, : 495 - 499
  • [35] Recent Insights into the Pathophysiology of Omental Metastases
    Koppe, Manuel J.
    Nagtegaal, Iris D.
    de Wilt, Johannes H. W.
    Ceelen, Wim P.
    JOURNAL OF SURGICAL ONCOLOGY, 2014, 110 (06) : 670 - 675
  • [36] Delayed haemolytic and serologic transfusion reactions: pathophysiology, treatment and prevention
    Siddon, Alexa J.
    Kenney, Barton C.
    Hendrickson, Jeanne E.
    Tormey, Christopher A.
    CURRENT OPINION IN HEMATOLOGY, 2018, 25 (06) : 459 - 467
  • [37] Pathophysiology of bone metabolism
    Jakob, F.
    Seefried, L.
    Ebert, R.
    INTERNIST, 2008, 49 (10): : 1159 - +
  • [38] PATHOPHYSIOLOGY OF BONE INFECTION
    KAHN, DS
    PRITZKER, KP
    CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 1973, (96) : 12 - 19
  • [39] The pathophysiology of bone loss
    Dempster, DW
    CLINICS IN GERIATRIC MEDICINE, 2003, 19 (02) : 259 - +
  • [40] Thyroid carcinomas with brain or skull metastases
    Chen, HW
    Su, DH
    Chen, HW
    Chang, TC
    ENDOCRINOLOGIST, 2005, 15 (05): : 303 - 308
12345