Pathophysiology of bone metastases in serologic carcinomas

被引：0

作者：

Sauer, G. ^{[1
]}

Barth, T. F. E. ^{[1
]}

Moeller, P. ^{[1
]}

机构：

[1] Univ Ulm Klinikum, Inst Pathol, D-89081 Ulm, Germany

来源：

UROLOGE | 2007年 / 46卷 / 08期

关键词：

bone metastases; renal carcinoma; urothelial carcinoma; prostatic carcinoma;

D O I：

10.1007/s00120-007-1519-y

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The skeletal system is the most frequent metastatic site of hematogenous spread of urologic carcinomas. Osseus metastases are classified as osteoneutral, osteolytic, osteoblastic and combinations thereof. Osteolytic metastases lead to bone resorption by activating osteoclasts, while osteoblastic metastases stimulate osteoblasts by paracrine mechanisms. The local osteoblastic effect is associated with secondary systemic bone resorption. The use of bisphosphonates is now an established supportive therapy and newer treatment strategies including targeted intervention in the pathophysiology of bone metastases and radioimmunotherapy are being applied or will be coming soon.

引用

页码：888 / 890

页数：5

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